Herbal Medicines, Integrative Cancer Care

Personalizing Chinese medicine by integrating molecular features of diseases and herb ingredient information: application to acute myeloid leukemia

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ABSTRACT

Traditional Chinese Medicine (TCM) has been widely used as a complementary medicine in Acute Myeloid Leukemia (AML) treatment. In this study, we proposed a new classification of Chinese Medicines (CMs) by integrating the latest discoveries in disease molecular mechanisms and traditional medicine theory. We screened out a set of chemical compounds on basis of AML differential expression genes and chemical-protein interactions and then mapped them to Traditional Chinese Medicine Integrated Database. 415 CMs contain those compounds and they were categorized into 8 groups according to the Traditional Chinese Pharmacology. Pathway analysis and synthetic lethality gene pairs were applied to analyze the dissimilarity, generality and intergroup relations of different groups. We defined hub CM pairs and alternative CM groups based on the analysis result and finally proposed a formula to form an effective anti-AML prescription which combined the hub CM pairs with alternative CMs according to patients’ molecular features. Our method of formulating CMs based on patients’ stratification provides novel insights into the new usage of conventional CMs and will promote TCM modernization.

Personalizing Chinese medicine by integrating molecular features of diseases and herb ingredient information: application to acute myeloid leukemia

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Herbal Medicines

CRF receptor 1 antagonism and brain distribution of active components contribute to the ameliorative effect of rikkunshito on stress-induced anorexia

In conclusion, we demonstrated that the initiation of novelty stress-induced anorexia in aged mice is due to 5-HT2CR and CRFR1/MC4R activation. Our results also indicate that brain distributed components of RKT possessing CRFR1 and 5-HT2CR antagonistic activities may be partly involved in its ameliorative effect in this model. However, further investigation of other active components or combinations of these components is required to fully understand the effects of RKT.

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Scientific Reports 6, Article number: 27516 (2016)

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Herbal Medicines, Integrative Cancer Care

Bojungikki-Tang for Cancer-Related Fatigue (CRF)

Bojungikki-tang may have beneficial effects on cancer-related fatigue and quality of lives in cancer patients.

Bojungikki-Tang for Cancer-Related Fatigue: A Pilot Randomized Clinical Trial

Integrative Cancer Therapies (2014 Impact Factor: 2.361) 

December 2010, vol. 9 no. 4 331-338

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