Herbal Medicines, Integrative Cancer Care

Personalizing Chinese medicine by integrating molecular features of diseases and herb ingredient information: application to acute myeloid leukemia

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ABSTRACT

Traditional Chinese Medicine (TCM) has been widely used as a complementary medicine in Acute Myeloid Leukemia (AML) treatment. In this study, we proposed a new classification of Chinese Medicines (CMs) by integrating the latest discoveries in disease molecular mechanisms and traditional medicine theory. We screened out a set of chemical compounds on basis of AML differential expression genes and chemical-protein interactions and then mapped them to Traditional Chinese Medicine Integrated Database. 415 CMs contain those compounds and they were categorized into 8 groups according to the Traditional Chinese Pharmacology. Pathway analysis and synthetic lethality gene pairs were applied to analyze the dissimilarity, generality and intergroup relations of different groups. We defined hub CM pairs and alternative CM groups based on the analysis result and finally proposed a formula to form an effective anti-AML prescription which combined the hub CM pairs with alternative CMs according to patients’ molecular features. Our method of formulating CMs based on patients’ stratification provides novel insights into the new usage of conventional CMs and will promote TCM modernization.

Personalizing Chinese medicine by integrating molecular features of diseases and herb ingredient information: application to acute myeloid leukemia

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Integrative Cancer Care

You are quite “Lucky”, if you are not a cancer patient.

Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention

Science  24 Mar 2017:
Vol. 355, Issue 6331, pp. 1330-1334

Fig 3. 유전적 요인(Hereditary), 환경적 요인(Environmental)에 비해서, DNA replication에 의한 driver mutation (Replicative)의 비율이 여러 암종을 통틀어서도 매우 높다.jpg

Cancer and the unavoidable R factor

Most textbooks attribute cancer-causing mutations to two major sources: inherited and environmental factors. A recent study highlighted the prominent role in cancer of replicative (R) mutations that arise from a third source: unavoidable errors associated with DNA replication. Tomasetti et al. developed a method for determining the proportions of cancer-causing mutations that result from inherited, environmental, and replicative factors (see the Perspective by Nowak and Waclaw). They found that a substantial fraction of cancer driver gene mutations are indeed due to replicative factors. The results are consistent with epidemiological estimates of the fraction of preventable cancers.

Science, this issue p. 1330; see also p. 1266

Abstract

Cancers are caused by mutations that may be inherited, induced by environmental factors, or result from DNA replication errors (R). We studied the relationship between the number of normal stem cell divisions and the risk of 17 cancer types in 69 countries throughout the world. The data revealed a strong correlation (median = 0.80) between cancer incidence and normal stem cell divisions in all countries, regardless of their environment. The major role of R mutations in cancer etiology was supported by an independent approach, based solely on cancer genome sequencing and epidemiological data, which suggested that R mutations are responsible for two-thirds of the mutations in human cancers. All of these results are consistent with epidemiological estimates of the fraction of cancers that can be prevented by changes in the environment. Moreover, they accentuate the importance of early detection and intervention to reduce deaths from the many cancers arising from unavoidable R mutations.

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Integrative Cancer Care, Medical Acupuncture

Acupuncture May Stimulate Anticancer Immunity via Activation of Natural Killer Cells

Acupuncture stimulation increases the cytotoxicity of NK cells by promoting cross talk between the neurotransmitter network and immune system.

https://www.hindawi.com/journals/ecam/2011/481625/

Evidence-Based Complementary and Alternative Medicine, Volume 2011 (2011)

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Integrative Cancer Care

Tumors have found a bloody new way to grow and spread

Tumors have found a bloody new way to grow and spread

(By Mitch Leslie, Jun. 16, 2016)

Researchers knew at the time that tumors can induce the endothelial cells of normal blood vessels to form new supply lines into a tumor, a process called angiogenesis. But Hendrix and her colleagues contended that tumor cells themselves sometimes create their own blood-delivering tubes, a mechanism they dubbed vasculogenic mimicry (also known as vascular mimicry).

Tumors have found a bloody new way to grow and spread

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Integrative Cancer Care

Preventable Incidence and Mortality of Carcinoma Associated With Lifestyle Factors Among White Adults in the United States

A substantial cancer burden may be prevented through lifestyle modification. Primary prevention should remain a priority for cancer control.

A healthy lifestyle pattern was defined as never or past smoking (pack-years <5), no or moderate alcohol drinking (≤1 drink/d for women, ≤2 drinks/d for men), BMI of at least 18.5 but lower than 27.5, and weekly aerobic physical activity of at least 75 vigorous-intensity or 150 moderate-intensity minutes.

Preventable Incidence and Mortality of Carcinoma Associated With Lifestyle Factors Among White Adults in the United States  (JAMA Oncol. Published online May 19, 2016)

 

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Herbal Medicines, Integrative Cancer Care

Bojungikki-Tang for Cancer-Related Fatigue (CRF)

Bojungikki-tang may have beneficial effects on cancer-related fatigue and quality of lives in cancer patients.

Bojungikki-Tang for Cancer-Related Fatigue: A Pilot Randomized Clinical Trial

Integrative Cancer Therapies (2014 Impact Factor: 2.361) 

December 2010, vol. 9 no. 4 331-338

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