Integrative Cancer Care

You are quite “Lucky”, if you are not a cancer patient.

Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention

Science  24 Mar 2017:
Vol. 355, Issue 6331, pp. 1330-1334

Fig 3. 유전적 요인(Hereditary), 환경적 요인(Environmental)에 비해서, DNA replication에 의한 driver mutation (Replicative)의 비율이 여러 암종을 통틀어서도 매우 높다.jpg

Cancer and the unavoidable R factor

Most textbooks attribute cancer-causing mutations to two major sources: inherited and environmental factors. A recent study highlighted the prominent role in cancer of replicative (R) mutations that arise from a third source: unavoidable errors associated with DNA replication. Tomasetti et al. developed a method for determining the proportions of cancer-causing mutations that result from inherited, environmental, and replicative factors (see the Perspective by Nowak and Waclaw). They found that a substantial fraction of cancer driver gene mutations are indeed due to replicative factors. The results are consistent with epidemiological estimates of the fraction of preventable cancers.

Science, this issue p. 1330; see also p. 1266

Abstract

Cancers are caused by mutations that may be inherited, induced by environmental factors, or result from DNA replication errors (R). We studied the relationship between the number of normal stem cell divisions and the risk of 17 cancer types in 69 countries throughout the world. The data revealed a strong correlation (median = 0.80) between cancer incidence and normal stem cell divisions in all countries, regardless of their environment. The major role of R mutations in cancer etiology was supported by an independent approach, based solely on cancer genome sequencing and epidemiological data, which suggested that R mutations are responsible for two-thirds of the mutations in human cancers. All of these results are consistent with epidemiological estimates of the fraction of cancers that can be prevented by changes in the environment. Moreover, they accentuate the importance of early detection and intervention to reduce deaths from the many cancers arising from unavoidable R mutations.

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Medical Acupuncture

Acupuncture for stroke rehabilitation

Authors’ conclusions

From the available evidence, acupuncture may have beneficial effects on improving dependency, global neurological deficiency, and some specific neurological impairments for people with stroke in the convalescent stage, with no obvious serious adverse events. However, most included trials were of inadequate quality and size. There is, therefore, inadequate evidence to draw any conclusions about its routine use. Rigorously designed, randomised, multi-centre, large sample trials of acupuncture for stroke are needed to further assess its effects.

Source: Acupuncture for stroke rehabilitation – Yang – 2016 – The Cochrane Library – Wiley Online Library

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Integrative Cancer Care, Medical Acupuncture

Acupuncture May Stimulate Anticancer Immunity via Activation of Natural Killer Cells

Acupuncture stimulation increases the cytotoxicity of NK cells by promoting cross talk between the neurotransmitter network and immune system.

https://www.hindawi.com/journals/ecam/2011/481625/

Evidence-Based Complementary and Alternative Medicine, Volume 2011 (2011)

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Integrative Cancer Care, Medical Acupuncture

Effects from acupuncture in treating anxiety

Effects from acupuncture in treating anxiety: integrative review.

RESULTS:

among 514 articles, 67 were selected to be fully read and 19 were included. Among these, 11 were found to have strong evidence levels. (…) Its results showed positive and statistically significant effects from using acupuncture for treating subjects with anxiety.

CONCLUSION:

acupuncture seems to be a promising treatment for anxiety; however, there is a need for improving the methodological quality of the research on this field.

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Integrative Cancer Care

Patients Benefit From New Acupuncture Program – Seattle Children’s Hospital

Patients Benefit From New Acupuncture Program – Seattle Children’s Hospital

– Acupuncture at Seattle Children’s involves applying needles, magnets and/or manual pressure (called acupressure) to specific points throughout the body to stimulate those areas. The treatment can help with a number of problems hospitalized patients experience, including pain, nausea, anxiety, insomnia, fatigue, depression and more.

Yvette knows first-hand how beneficial acupuncture can be for cancer patients. While undergoing breast cancer treatment two years ago, she received acupuncture to manage the side effects. “It helped a great deal,” says Yvette. “Not just with pain, but also with fatigue.”

Gailon first used acupuncture at Seattle Children’s to relieve the discomfort caused by her tumor. “Acupuncture and acupressure helped manage the pain in addition to some of the other ways to manage pain,” says Gailon.-

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Integrative Cancer Care

Tumors have found a bloody new way to grow and spread

Tumors have found a bloody new way to grow and spread

(By Mitch Leslie, Jun. 16, 2016)

Researchers knew at the time that tumors can induce the endothelial cells of normal blood vessels to form new supply lines into a tumor, a process called angiogenesis. But Hendrix and her colleagues contended that tumor cells themselves sometimes create their own blood-delivering tubes, a mechanism they dubbed vasculogenic mimicry (also known as vascular mimicry).

Tumors have found a bloody new way to grow and spread

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Herbal Medicines

CRF receptor 1 antagonism and brain distribution of active components contribute to the ameliorative effect of rikkunshito on stress-induced anorexia

In conclusion, we demonstrated that the initiation of novelty stress-induced anorexia in aged mice is due to 5-HT2CR and CRFR1/MC4R activation. Our results also indicate that brain distributed components of RKT possessing CRFR1 and 5-HT2CR antagonistic activities may be partly involved in its ameliorative effect in this model. However, further investigation of other active components or combinations of these components is required to fully understand the effects of RKT.

 

Click here to read the paper.

Scientific Reports 6, Article number: 27516 (2016)

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