Herbal Medicines, Integrative Cancer Care

To improve appetite loss in patients with lung cancer undergoing chemotherapy. – Use of the herbal formula ‘YukgunjaTang’

Effect of rikkunshi-to treatment on chemotherapy-induced appetite loss in patients with lung cancer: A prospective study

Exp Ther Med. 2016 Jan; 11(1): 243–246. Published online 2015 Nov 27.
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In patients treated with CBDCA-containing chemotherapy, food intake at day 7 following the initiation of chemotherapy in the rikkunshi-to treatment group was significantly higher compared with the group not treated with rikkunshi-to (P=0.0078).
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Integrative Cancer Care

Do not get so fat. Excessive adipose tissue can induce cancer.

Fibroblast growth factor receptor is a mechanistic link between visceral adiposity and cancer

Oncogene advance online publication 7 August 2017

Abstract

Epidemiological evidence implicates excess adipose tissue in increasing cancer risk. Despite a steeply rising global prevalence of obesity, how adiposity contributes to transformation (stage a non-tumorigenic cell undergoes to become malignant) is unknown. To determine the factors in adipose tissue that stimulate transformation, we used a novel ex vivosystem of visceral adipose tissue (VAT)-condition medium-stimulated epithelial cell growth in soft agar. To extend this system in vivo, we used a murine lipectomy model of ultraviolet light B-induced, VAT-promoted skin tumor formation. We found that VAT from mice and obese human donors stimulated growth in soft agar of non-tumorigenic epithelial cells. The difference in VAT activity was associated with fibroblast growth factor-2 (FGF2) levels. Moreover, human and mouse VAT failed to stimulate growth in soft of agar in cells deficient in FGFR-1 (FGF2 receptor). We also demonstrated that circulating levels of FGF2 were associated with non-melanoma tumor formation in vivo. These data implicate FGF2 as a major factor VAT releases to transform epithelial cells—a novel, potential pathway of VAT-enhanced tumorigenesis. Strategies designed to deplete VAT stores of FGF2 or inhibit FGFR-1 in abdominally obese individuals may be important cancer prevention strategies as well as adjuvant therapies for improving outcomes.

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Herbal Medicines, Integrative Cancer Care

Personalizing Chinese medicine by integrating molecular features of diseases and herb ingredient information: application to acute myeloid leukemia

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ABSTRACT

Traditional Chinese Medicine (TCM) has been widely used as a complementary medicine in Acute Myeloid Leukemia (AML) treatment. In this study, we proposed a new classification of Chinese Medicines (CMs) by integrating the latest discoveries in disease molecular mechanisms and traditional medicine theory. We screened out a set of chemical compounds on basis of AML differential expression genes and chemical-protein interactions and then mapped them to Traditional Chinese Medicine Integrated Database. 415 CMs contain those compounds and they were categorized into 8 groups according to the Traditional Chinese Pharmacology. Pathway analysis and synthetic lethality gene pairs were applied to analyze the dissimilarity, generality and intergroup relations of different groups. We defined hub CM pairs and alternative CM groups based on the analysis result and finally proposed a formula to form an effective anti-AML prescription which combined the hub CM pairs with alternative CMs according to patients’ molecular features. Our method of formulating CMs based on patients’ stratification provides novel insights into the new usage of conventional CMs and will promote TCM modernization.

Personalizing Chinese medicine by integrating molecular features of diseases and herb ingredient information: application to acute myeloid leukemia

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Integrative Cancer Care

You are quite “Lucky”, if you are not a cancer patient.

Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention

Science  24 Mar 2017:
Vol. 355, Issue 6331, pp. 1330-1334

Fig 3. 유전적 요인(Hereditary), 환경적 요인(Environmental)에 비해서, DNA replication에 의한 driver mutation (Replicative)의 비율이 여러 암종을 통틀어서도 매우 높다.jpg

Cancer and the unavoidable R factor

Most textbooks attribute cancer-causing mutations to two major sources: inherited and environmental factors. A recent study highlighted the prominent role in cancer of replicative (R) mutations that arise from a third source: unavoidable errors associated with DNA replication. Tomasetti et al. developed a method for determining the proportions of cancer-causing mutations that result from inherited, environmental, and replicative factors (see the Perspective by Nowak and Waclaw). They found that a substantial fraction of cancer driver gene mutations are indeed due to replicative factors. The results are consistent with epidemiological estimates of the fraction of preventable cancers.

Science, this issue p. 1330; see also p. 1266

Abstract

Cancers are caused by mutations that may be inherited, induced by environmental factors, or result from DNA replication errors (R). We studied the relationship between the number of normal stem cell divisions and the risk of 17 cancer types in 69 countries throughout the world. The data revealed a strong correlation (median = 0.80) between cancer incidence and normal stem cell divisions in all countries, regardless of their environment. The major role of R mutations in cancer etiology was supported by an independent approach, based solely on cancer genome sequencing and epidemiological data, which suggested that R mutations are responsible for two-thirds of the mutations in human cancers. All of these results are consistent with epidemiological estimates of the fraction of cancers that can be prevented by changes in the environment. Moreover, they accentuate the importance of early detection and intervention to reduce deaths from the many cancers arising from unavoidable R mutations.

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Integrative Cancer Care, Medical Acupuncture

Acupuncture May Stimulate Anticancer Immunity via Activation of Natural Killer Cells

Acupuncture stimulation increases the cytotoxicity of NK cells by promoting cross talk between the neurotransmitter network and immune system.

https://www.hindawi.com/journals/ecam/2011/481625/

Evidence-Based Complementary and Alternative Medicine, Volume 2011 (2011)

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Integrative Cancer Care, Medical Acupuncture

Effects from acupuncture in treating anxiety

Effects from acupuncture in treating anxiety: integrative review.

RESULTS:

among 514 articles, 67 were selected to be fully read and 19 were included. Among these, 11 were found to have strong evidence levels. (…) Its results showed positive and statistically significant effects from using acupuncture for treating subjects with anxiety.

CONCLUSION:

acupuncture seems to be a promising treatment for anxiety; however, there is a need for improving the methodological quality of the research on this field.

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Integrative Cancer Care

Patients Benefit From New Acupuncture Program – Seattle Children’s Hospital

Patients Benefit From New Acupuncture Program – Seattle Children’s Hospital

– Acupuncture at Seattle Children’s involves applying needles, magnets and/or manual pressure (called acupressure) to specific points throughout the body to stimulate those areas. The treatment can help with a number of problems hospitalized patients experience, including pain, nausea, anxiety, insomnia, fatigue, depression and more.

Yvette knows first-hand how beneficial acupuncture can be for cancer patients. While undergoing breast cancer treatment two years ago, she received acupuncture to manage the side effects. “It helped a great deal,” says Yvette. “Not just with pain, but also with fatigue.”

Gailon first used acupuncture at Seattle Children’s to relieve the discomfort caused by her tumor. “Acupuncture and acupressure helped manage the pain in addition to some of the other ways to manage pain,” says Gailon.-

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