CRF receptor 1 antagonism and brain distribution of active components contribute to the ameliorative effect of rikkunshito on stress-induced anorexia

In conclusion, we demonstrated that the initiation of novelty stress-induced anorexia in aged mice is due to 5-HT_2CR and CRFR1/MC4R activation. Our results also indicate that brain distributed components of RKT possessing CRFR1 and 5-HT_2CR antagonistic activities may be partly involved in its ameliorative effect in this model. However, further investigation of other active components or combinations of these components is required to fully understand the effects of RKT.

 

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Scientific Reports 6, Article number: 27516 (2016)